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Genetic Varation Analysis |
We use a variety of currently available technologies to study genetic variation in case-control designs:
- Polymorphism detection and analysis:
Using Next-generation sequencing technologies we can support sequencing and re-sequencing for mutation testing or discovery.
- Genome wide association studies:
Our scalable SNP platform is capable of delivering quality assessment and statistical association tests for both Affymetrix and Illumina data.
- Copy number variation:
We use the latest tools to determine copy number variation and loss of heterozygosity in samples.
- Single feature polymorphism (SFP):
In the absence of a defined genome we find that GeneChip or BeadArray expression arrays can be used for detecting genetic polymorphisms between two populations. This in-house SFP calling method based on a splice-site prediction algorithm has been successfully experimentally validated in several crop plant studies.
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