| RATstream - goals |
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Ultimately, the project hopes to deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed and validated independently and model specific data will be incorporated into an integrated database. In a joint effort the project sub-groups will develop a novel and comprehensive set of behavioural and physiological phenotyping procedures including PET, DTI and microarray technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in these models. The resulting biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies. RATstream™ will provide proof of concept that applying novel substances will delay or prevent neurodegeneration. Furthermore, these rat models will be used to scrutinise novel experimental, pre-clinical treatments chiefly with regard to effectiveness, side-effects, applicability, and their transferability to human treatment. Project products generated by the RATstream™ consortium:
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