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European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment.
Project call: FP6-2005-LIFESCIHEALTH-7
Project #: LSHM-037846
Website: http://www.ratstream.eu/
Project abstract
RATstream™ is an ambitious European project that aims to characterise and use three unique transgenic rat models of neurodegenerative diseases which, in humans, present with a wide range of neurological and psychiatric phenotypes:
- transgenic rat model of Huntington’s Disease (HD)
- transgenic rat model of Parkinson’s Disease (PD) over expressing alpha-Synuclein with the A30P mutation, and
- transgenic rat model of spinocerebellar ataxia type 17 (SCA17) with 64 expanded CAG repeats in the TATA binding protein.
The three diseases all have a major impact on the health care system and were carefully chosen in respect to their (a) neurological and psychiatric signs, (b) their lack or limitations in respect to currently available treatments in humans, (c) their basically fatal progression, and (d) their different but also overlapping pathogenesis.
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