| MoodInFlame - Focus |
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This project focuses on the pathophysiology of mood disorders, including animal models, and aims at introducing experimental medicine models at the interphase between Phase I and Phase II clinical trials. The research directly improves early diagnosis and clearly leads to approaches for tackling the problem of prevention of mood disorders. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and aims at a personalised treatment of patients on the basis of their activated IRS. The animal models, the OBX rat, GS rat and NOD mouse, are heavily relied upon in this study and allow the testing of anti-inflammatory therapeutics to know their mechanism of action at the brain. It is anticipated that this project will lead to the development of clinically applicable assays to detect early stages of major mood disorders which can be targeted by intervention strategies to halt or slow the development of major mood disorders. The subsequent exploitation of these assays and drugs will have a very significant impact upon the general health state of the population and an extraordinarily positive effect on health costs in Europe. |