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Diagnostic biomarker platform for early diagnosis, treatment and prevention of mood disorders targeting the activated inflammatory response system.
Project call: FP7- HEALTH-2007-2.2.1-8
Project #:
Website: http://www2.i-med.ac.at/psychlab/links.html
Project Abstract
“From mood disorders to experimental models”
A consortium of 14 European Universities/Research Institutes and 4 SME’s harbouring expert psychiatrists, neuroscientists, immunologists, cell biologists, biochemists, pharmacologists and bioinformaticians have come together for a 4 year project with an overall objective proposal to:
- Introduce into clinical practice the two sets of biomarker tests:
- To identify mood disorder patients and individuals at risk of mood disorders characterised by an activated inflammatory response system (IRS) and/or a disturbed metabolism of tryptophan and
- To treat these patients and individuals with drugs counteracting the consequences of the activated IRS/disturbed metabolism of tryptophan.
- Further explore three animal models characterised by an activated IRS, an abnormal tryptophan metabolism and a depressive behaviour, to study in particular:
- The pathogenesis of inflammation-related mood disorders on the level of an aberrant neuron-microglia-astrocyte interaction, and
- The efficacy and working mechanism of anti-inflammatory drugs and of drugs restoring tryptophan metabolism on depressive-like behaviour.
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